Proteins, proteomics

alpha-1 acid glycoprotein

Alpha-1-acid glycoprotein (AGP) or orosomucoid (ORM) is an acute phase protein synthesized in response to pro-inflammatory cytokines early in the inflammatory response.

AGP gene expression is controlled by a combination of the major regulatory mediators – glucocorticoids and a cytokine network involving IL-1β, TNF-α, IL-6, and IL-6 related cytokines. Human AGP is a 41-43 kDa glycoprotein with single chain of 183 amino acids plus five to six highly sialylated complex-type-N-linked glycans, rendering the molecule heavily glycosylated (45%). Binding affinity and immunomodulatory activities of AGP are mostly dependent on carbohydrate composition.

Alpha-1-acid glycoprotein. Fournier T, Medjoubi-N N, Porquet D. Biochim Biophys Acta. 2000 Oct 18;1482(1-2):157-71.


Labels: , , , ,

. . . since 11/21/06