AGP gene expression is controlled by a combination of the major regulatory mediators – glucocorticoids and a cytokine network involving IL-1β, TNF-α, IL-6, and IL-6 related cytokines. Human AGP is a 41-43 kDa glycoprotein with single chain of 183 amino acids plus five to six highly sialylated complex-type-N-linked glycans, rendering the molecule heavily glycosylated (45%). Binding affinity and immunomodulatory activities of AGP are mostly dependent on carbohydrate composition.
Alpha-1-acid glycoprotein. Fournier T, Medjoubi-N N, Porquet D. Biochim Biophys Acta. 2000 Oct 18;1482(1-2):157-71.
tags [Proteins] [acute phase] [alpha-1-acid glycoprotein] [inflammation] [cytokine]