Proteins, proteomics

alpha 1-antitrypsin

Alpha 1-antitrypsin or α1-antitrypsin (A1AT) or alpha-1 proteinase inhibitor (α1-PI) is an an acute phase protein synthesized in response to pro-inflammatory cytokines early in the inflammatory response.

A1AT is a 52 kDa prototypical serine protease inhibitor (serpin) that protects against enzymes released by inflammatory cells, particularly elastase, which is released from neutrophilic granules. A1AT forms covalent bonds with both elastase and trypsin, irreversibly inactivating these proteolytic enzymes.

Alpha 1-antitrypsin deficiency is a hereditary disorder in which inability to inactivate elastase and trypsin allows inflammatory tissue breakdown, causing pulmonary emphysema and hepatic cirrhosis in severe cases.


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. . . since 11/21/06