Kringle domains are found in several serine proteases, including prothrombin (with two kringle domains) and urokinase-type plasminogen activator, in ROR-like receptors, and they participate in protein-protein interactions with blood coagulation factors.
Urokinase-type plasminogen activator is a strong plasminogen activator which specifically cleaves the proenzyme/zymogen plasminogen to form the active enzyme plasmin.[s] Ror-family RTKs are characterized by the intracellular tyrosine kinase domains, highly related to those of the Trk-family RTKs, and by the extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains.[pm]
 plasminogen, rotate human plasminogen, primary structure 
tags [Proteins] [kringle domains] [serine proteases] [prothrombin]