Proteins

Proteins are complex, macromolecules comprised of amino acids linked by peptide bonds into long chains. The sequence (primary structure) a...

An adaptor protein links components in signaling pathways by acting as an accessory to the chief proteins in a signal transduction pathwa...

Alpha-1-acid glycoprotein ( AGP ) or orosomucoid ( ORM ) is an acute phase protein synthesized in response to pro-inflammatory cytokines ...

alpha 1-Antichymotrypsin ( ACT ) is an an acute phase protein synthesized in response to pro-inflammatory cytokines early in the inflamma...

Alpha 1-antitrypsin or α1-antitrypsin ( A1AT ) or alpha-1 proteinase inhibitor (α1-PI) is an an acute phase protein synthesized in respo...

Alpha-2 macroglobulin ( A2M ), α-2 macroglobulin is an an acute phase protein synthesized in response to pro-inflammatory cytokines earl...

Caspase recruitment domains , or CARD domains are found in many proteins, particularly those that evoke inflammatory responses or apoptos...

Coagulation factors participate in the coagulation cascade, which is initiated within 20 seconds of an injury to the endothelial cells that...

Collagen is the chief structural protein of connective tissue in mammals, located mostly in the extracellular matrix . Collagen comprises l...

C-reactive protein is an acute phase protein produced by the liver within 6 hours of an acute inflammatory stimulus . Levels peak after ab...

A binding domain is that sequence of amino acids in a protein/protein family to which a specific ligand binds. As such, domains are vital ...

EF-hand domains comprise two helices that are arranged roughly perpendicular to each other and connected by a loop. Most EF-hand units are ...

Ferritin is an an acute phase protein synthesized in response to pro-inflammatory cytokines early in the inflammatory response . Ferritin...

Fibronectin ( FN ) is a high molecular weight, multidomain glycoprotein, comprising about 5% by weight of carbohydrate. Fibronectin exhib...

Granulysin is a 74-aa basic protein released from human cytolytic T lymphocytes ( CTL , Tc ) and natural killer cells ( NK ). 'The fiv...

Haptoglobins (Hp) are acute phase proteins synthesized in response to pro-inflammatory cytokines early in the inflammatory response . Hap...

The immunoglobulin superfamily comprises an evolutionarily ancient, widely expressed, constitutive or long-term up-regulated family of gly...

Kringle domains , named for Scandinavian pastries, are conserved sequences that fold into large loops (stabilized by 3 disulfide linkages)...

Mannose binding protein ( MBP ) or mannan-binding lectin ( MBL ) is a member of the collectin family, and is a C−type serum lectin that p...

Modulator proteins regulate the activity of other proteins. Calmodulin (Ca2+-regulated modulator protein, CaM ) is a ubiquitous eukaryotic...

Molecular motors are proteins or protein complexes that transform chemical energy – derived from ATP hydrolysis – into mechanical work. Mol...

NF-κB , Nuclear Factor kappa Bs, are ubiquitous transcription factors involved in responses to cellular stressors such as cytokines , free...