PH family

The pleckstrin homology (PH) domain family includes proteins with the PH domain, which is a 100-120 aa module found in a multitude of intracellullar proteins with widepread functions. Many proteins containing PH domains participate in signaling cascades. Other classes of proteins carry a PH domain, including cytoskeletal proteins such as spectrin. [w]

The inositol phospolipids are particularly effective in specific binding to PH domains of cellular proteins. Phosphatidylinositol is an important lipid, both as a participant in essential metabolic processes and as a key membrane constituent. In addition to their role as negatively charged building blocks of membranes, the inositol phospolipids (including the phosphatidylinositol phosphates, or 'polyphosphoinositides') appear to have crucial roles in interfacial binding of proteins and in the regulation of proteins at the cell interface.

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tags [Proteins]
[pleckstrin homology domain] [signaling] [phosphatidylinositol]